Alprenolol is a non-selective beta (β)-locker and a 5-HT_1A receptor antagonist. This drug is used for treating angina pectoris-chest pain caused by ischemia. It is also known as Alfeprol, Alpheprol, and Alprenololum. The AstraZeneca Pharmaceutical Company no longer markets this drug; however, it is still available at other pharmaceutical companies.

Alprenolol Identification

CAS number: 13655-52-2

ATC code: C07AA01

PubChem: CID 2119

ChemSpider: 2035

UNII: 877K5MQ27W

KEGG: D07156

ChEBI: CHEBI: 51211

ChEMBL: CHEMBL266195

Alprenolol Formula

The formula for this amine is C₁₅H₂₃NO₂.

Picture 1 – Agmatine

Alprenolol IUPAC Name

The IUPAC (The International Union of Pure and Applied Chemistry) name for this drug is 1- (propan-2-ylamino) -3- (2-prop-2- enylphenoxy) propan-2-ol.

Alprenolol Properties

Following are some of the basic properties of this amine:

Phase: It has a solid phase.

Molar Mass: The molar mass of this substance is 249.34 g/mol.

Melting Point: It has a melting point of 108 °C.

Half-life: 2 to 3 hours.

Alprenolol Uses

This drug can cause selective β₁-adrenoceptor blockade as it functions as a partial agonist. The pharmacology of this drug is similar to Atenolol. It is taken orally for the treatment of angina. It is the chest pain caused by reduced oxygen supply and waste removal due to lack of blood. It is also used for treating hypertension, arrhythmia, ventricular tachycardias and atrial fibrillation.

Alprenolol Pharmacology

Alprenolol impairs the conduction of AV node and decreases the rate of sinus. It may also be capable of increasing plasma triglyceride as well as decreasing the levels of HDL-cholesterol. This non-polar hydrophobic drug has moderate lipid solubility. Alprenolol has very low intrinsic sympathomimetic activity as well as little direct myocardial depressant activity.

Alprenolol Adverse Drug Reactions

This drug may cause various adverse reactions in humans such as:

• Bradycardia
• Hypotension
• Heart block
• Heart failure
• Fatigue
• Bronchospasm
• Skin rash
• Pneumonitis
• Pulmonary and retroperitoneal fibrosis
• Pruritus
• Reversible alopoecia
• Lupus-like syndrome
• Peripheral neuropathy
• Sclerosing peritonitis
• Hematological reactions
• Muscle cramps

Alprenolol Availability

The AstraZeneca Company does not market this drug any longer. One may avail this drug generically or from some other pharmaceutical companies.

References
1. http://en.wikipedia.org/wiki/Alprenolol
2. https://www.mims.com/india/drug/info/alprenolol?type=full&mtype=generic
3. http://www.druglib.com/activeingredient/alprenolol/